Happy Holidays and New year from the EMDB! Please be advised that the EMDB team will be operating at reduced capacity between December 15th - January 12th. With this in mind we would ask that you be prepared for longer reply times through both our helpdesk system and the OneDep deposition system. well done on a productive 2025, wishing you all the best and we will see you in 2026!
EMD-52520
Pre-clinical characterization of novel multi-client inhibitors of Sec61 with broad anti-tumor activity
EMD-52520
Single-particle2.6 Å
Deposition: 13/01/2025Map released: 16/07/2025
Last modified: 30/07/2025
Sample Organism:
Ovis aries
Sample: Sec61 translocon complex with small molecule
Fitted models: 9hz5
Deposition Authors: Shahid R, Paavilainen VO
Sample: Sec61 translocon complex with small molecule
Fitted models: 9hz5
Deposition Authors: Shahid R, Paavilainen VO
Preclinical characterization of novel multi-client inhibitors of Sec61 with broad antitumor activity.
Lowe E,
Anderl JL 
,
Bade D,
Delgado-Martin C,
Dong C,
Fan RA,
Fang Y,
Jiang J,
Johnson HWB,
Kempema A,
McGilvray P,
McMinn D,
Millare B,
Muchamuel T,
Poweleit N,
Qian Y,
Rehan S,
Scapin G,
Sugahara A,
Tranter D,
Tuch B,
Wang J,
Wang L,
Whang JA,
Zuno-Mitchell P,
Paavilainen VO,
Park E,
Taunton J,
Kirk CJ,
Anand NK
(2025) J Pharmacol Exp Ther , 392 , 103634 - 103634
,
Bade D,
Delgado-Martin C,
Dong C,
Fan RA,
Fang Y,
Jiang J,
Johnson HWB,
Kempema A,
McGilvray P,
McMinn D,
Millare B,
Muchamuel T,
Poweleit N,
Qian Y,
Rehan S,
Scapin G,
Sugahara A,
Tranter D,
Tuch B,
Wang J,
Wang L,
Whang JA,
Zuno-Mitchell P,
Paavilainen VO,
Park E,
Taunton J,
Kirk CJ,
Anand NK
(2025) J Pharmacol Exp Ther , 392 , 103634 - 103634
Grant Support:
- Academy of Finland: 338836 (Finland)
- Jane and Aatos Erkko Foundation: (Finland)