EMD-52211

Single-particle
2.1 Å
EMD-52211
3D View Gallery
Deposition: 28/11/2024
Map released: 04/06/2025
Last modified: 17/12/2025
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-52211
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3D volume (map.gz) Experimental metadata (xml) Experimental Metadata (cif.gz)
Map-only Validation report (pdf.gz) Map-only Validation report (cif.gz) Map-only Validation report (xml.gz)
Map and PDB model 9hj8 summary report (pdf.gz) Map and 9hj8 FULL report (pdf.gz)
EMICSS annotations (xml)

TRPML1 in complex with compound 5

EMD-52211

Single-particle
2.1 Å
EMD-52211
3D View Gallery
Deposition: 28/11/2024
Map released: 04/06/2025
Last modified: 17/12/2025
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens
Sample: Mucolipin-1
Fitted models: 9hj8

Deposition Authors: Reeks J , Mahajan P, Clark M, Cowan SR, Di Daniel E, Earl CP, Fisher S, Holvey RS, Jackson SM, Lloyd-Evans E, Morgillo CM, Mortenson PN, O'Reilly M, Richardson CJ, Schopf P, Tams DM, Waller-Evans H, Ward SE, Whibley S, Williams PA, Johnson CN
High throughput cryo-EM provides structural understanding for modulators of the lysosomal ion channel TRPML1.
Reeks J , Mahajan P, Clark M, Cowan SR, Di Daniel E, Earl CP, Fisher S, Holvey RS, Jackson SM, Lloyd-Evans E, Morgillo CM, Mortenson PN, O'Reilly M, Richardson CJ, Schopf P, Tams DM, Waller-Evans H, Ward SE, Whibley S, Williams PA, Johnson CN
(2025) Structure , 33 , 1374 - 1385.e7
PUBMED: 40532704
DOI: doi:10.1016/j.str.2025.05.014
ISSN: 0969-2126
ASTM: STRUE6
Grant Support: