EMD-51881
Cryo-EM structure of DDB1-CRBN in complex with NK7-902 and NEK7
EMD-51881
Single-particle3.4 Å
Deposition: 22/10/2024Map released: 25/06/2025
Last modified: 05/08/2026
Sample Organism:
Homo sapiens
Sample: Ternary complex of hDDB1-hCRBN with NK7-902 and hNEK7
Fitted models: 9h59
Deposition Authors: Khoshouei M
,
Schroeder M
Sample: Ternary complex of hDDB1-hCRBN with NK7-902 and hNEK7
Fitted models: 9h59
Deposition Authors: Khoshouei M
,
Schroeder M
A cereblon (CRBN) molecular glue degrader of NIMA-related kinase 7 (NEK7) reveals a context-dependent role in NLRP3 inflammasome activation
Sylvain A,
Stoehr N,
Ma F,
Cernijenko A,
Schroder M,
Khoshouei M ,
Vogelsanger M,
Schoenboerner M,
Burke A,
Pasupuleti R,
Solomon J,
Paulk J,
Xu L,
Dawson J,
Begue D,
Lefeuvre P,
Ahrne E,
Hofmann A,
Dickson CJ,
Arabin P,
Zimmerlin A,
Kiffe M,
Froehlicher M,
Boersig T,
Elhajouji A,
Brichet M,
Menon S,
Liu S,
Mueller M,
Wartchow C,
Lin J,
Cardona Gloria Y,
Dickhofer S,
Weber ANR,
Welzel T,
Kuemmerle-Deschner J,
Farady CJ,
Pulz R,
Bornancin F,
Buckley DL,
Bassi ZI
(2024) bioRxiv
,
Vogelsanger M,
Schoenboerner M,
Burke A,
Pasupuleti R,
Solomon J,
Paulk J,
Xu L,
Dawson J,
Begue D,
Lefeuvre P,
Ahrne E,
Hofmann A,
Dickson CJ,
Arabin P,
Zimmerlin A,
Kiffe M,
Froehlicher M,
Boersig T,
Elhajouji A,
Brichet M,
Menon S,
Liu S,
Mueller M,
Wartchow C,
Lin J,
Cardona Gloria Y,
Dickhofer S,
Weber ANR,
Welzel T,
Kuemmerle-Deschner J,
Farady CJ,
Pulz R,
Bornancin F,
Buckley DL,
Bassi ZI
(2024) bioRxiv
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