EMD-50741

Single-particle
3.16 Å
EMD-50741
3D View Gallery
Deposition: 24/06/2024
Map released: 05/03/2025
Last modified: 23/07/2025
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-50741

Archive Files (Depositor)

Primary 3D volume (map.gz) Half-map 1 Half-map 2 (map.gz) Experimental metadata (xml) Experimental metadata (cif.gz)

Validation (wwPDB)

Map-only validation report (pdf.gz) Map-9ft7 summary report (pdf.gz) Map-9ft7 FULL report (pdf.gz)

EMDB Annotations

EMICSS entry mapping (xml)

EMDB Files

VA raw map (map) VA resolution mask (mrc)

Structure of the human two pore domain potassium ion channel THIK-1 (K2P13.1) in a closed conformation

EMD-50741

Single-particle
3.16 Å
EMD-50741
3D View Gallery
Deposition: 24/06/2024
Map released: 05/03/2025
Last modified: 23/07/2025
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens
Sample: K2P13.1 homodimer
Fitted models: 9ft7

Deposition Authors: Rodstrom KEJ, Tucker SJ
Cryo-EM structure of the human THIK-1 K2P K + channel reveals a lower Y gate regulated by lipids and anesthetics.
Rodstrom KEJ, Eymsh B, Proks P, Hayre MS , Cordeiro S, Mendez-Otalvaro E, Madry C , Rowland A, Kopec W , Newstead S , Baukrowitz T, Schewe M , Tucker SJ
(2025) Nat Struct Mol Biol , 32 , 1167 - 1174
PUBMED: 40011745
DOI: doi:10.1038/s41594-025-01497-6
ISSN: 1545-9985