EMD-50741

Single-particle
3.16 Å
EMD-50741
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Deposition: 24/06/2024
Map released: 05/03/2025
Last modified: 23/07/2025
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-50741
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3D volume (map.gz) Experimental metadata (xml) Experimental Metadata (cif.gz)
Map-only Validation report (pdf.gz) Map-only Validation report (cif.gz) Map-only Validation report (xml.gz)
Map and PDB model 9ft7 summary report (pdf.gz) Map and 9ft7 FULL report (pdf.gz)
EMICSS annotations (xml)

Structure of the human two pore domain potassium ion channel THIK-1 (K2P13.1) in a closed conformation

EMD-50741

Single-particle
3.16 Å
EMD-50741
3D View Gallery
Deposition: 24/06/2024
Map released: 05/03/2025
Last modified: 23/07/2025
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens
Sample: K2P13.1 homodimer
Fitted models: 9ft7

Deposition Authors: Rodstrom KEJ, Tucker SJ
Cryo-EM structure of the human THIK-1 K2P K + channel reveals a lower Y gate regulated by lipids and anesthetics.
Rodstrom KEJ, Eymsh B, Proks P, Hayre MS , Cordeiro S, Mendez-Otalvaro E, Madry C, Rowland A, Kopec W , Newstead S , Baukrowitz T , Schewe M , Tucker SJ
(2025) Nat Struct Mol Biol , 32 , 1167 - 1174
PUBMED: 40011745
DOI: doi:10.1038/s41594-025-01497-6
ISSN: 1545-9985