EMD-50336
Cryo-EM structure of the ternary DARPin NY_1/HLA-A0201/NY-ESO1 complex.
EMD-50336
Single-particle3.1 Å
Deposition: 17/05/2024Map released: 28/05/2025
Last modified: 10/12/2025
Sample Organism:
Homo sapiens,
synthetic construct
Sample: Ternary complex formed between the DARPin NY_1 and HLA-A0201/hb2m/NY-ESO1_157-165(9V)
Fitted models: 9fe1
Deposition Authors: Schulte T, Wallden K, Carroni M, Sandalova T, Walser M, Mueller S, Venetz N, Achour A
Sample: Ternary complex formed between the DARPin NY_1 and HLA-A0201/hb2m/NY-ESO1_157-165(9V)
Fitted models: 9fe1
Deposition Authors: Schulte T, Wallden K, Carroni M, Sandalova T, Walser M, Mueller S, Venetz N, Achour A
Development of DARPin T cell engagers for specific targeting of tumor-associated HLA/peptide complexes.
Venetz-Arenas N,
Schulte T,
Muller S,
Wallden K,
Fischer S,
Resink T 
,
Kadri N,
Paladino M,
Pina N,
Radom F,
Villemagne D,
Bruckmaier S,
Cornelius A,
Hospodarsch T,
Alici E,
Ljunggren HG,
Chambers BJ,
Han X,
Sun R,
Carroni M,
Levitsky V,
Sandalova T,
Walser M,
Achour A
(2025) iScience , 28 , 113926 - 113926
,
Kadri N,
Paladino M,
Pina N,
Radom F,
Villemagne D,
Bruckmaier S,
Cornelius A,
Hospodarsch T,
Alici E,
Ljunggren HG,
Chambers BJ,
Han X,
Sun R,
Carroni M,
Levitsky V,
Sandalova T,
Walser M,
Achour A
(2025) iScience , 28 , 113926 - 113926
Grant Support:
- Knut and Alice Wallenberg Foundation: (Sweden)
- Cancerfonden: (Sweden)
- Swedish Research Council: (Sweden)