EMD-49896

Single-particle
3.58 Å
EMD-49896
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Deposition: 24/03/2025
Map released: 17/12/2025
Last modified: 17/12/2025
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-49896
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3D volume (map.gz) Experimental metadata (xml) Experimental Metadata (cif.gz)
Map-only Validation report (pdf.gz) Map-only Validation report (cif.gz) Map-only Validation report (xml.gz)
Map and PDB model 9nww summary report (pdf.gz) Map and 9nww FULL report (pdf.gz)
EMICSS annotations (xml)

Single-particle cryo-EM structure of the first variant of mobilized colistin resistance (MCR-1) in its ligand-bound state

EMD-49896

Single-particle
3.58 Å
EMD-49896
3D View Gallery
Deposition: 24/03/2025
Map released: 17/12/2025
Last modified: 17/12/2025
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Escherichia coli, Homo sapiens
Sample: PE- and KLA-bound MCR-1 complex with Fab fragment
Fitted models: 9nww

Deposition Authors: Zinkle AP, Bunuro-Batista M, Herrera CM, Erramilli SK, Kloss B, Ashraf KU, Nosol K, Zhang G, Cater RJ, Marty MT, Kossiakoff AA, Trent MS, Nygaard R, Stansfeld PJ, Mancia F
Mechanistic basis of antimicrobial resistance mediated by the phosphoethanolamine transferase MCR-1.
Zinkle AP, Batista MB, Herrera CM, Erramilli SK, Kloss B, Ashraf KU, Nosol K, Zhang G, Cater RJ, Marty MT, Kossiakoff AA, Trent MS, Nygaard R, Stansfeld PJ, Mancia F
(2025) Nat Commun , 16 , 10516 - 10516
PUBMED: 41298376
DOI: doi:10.1038/s41467-025-65515-3
ISSN: 2041-1723