EMD-49458

Single-particle
5.0 Å
EMD-49458
3D View Gallery
Deposition: 26/02/2025
Map released: 13/05/2026
Last modified: 13/05/2026
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-49458
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3D volume (map.gz) Experimental metadata (xml) Experimental Metadata (cif.gz)
Map-only Validation report (pdf.gz) Map-only Validation report (cif.gz) Map-only Validation report (xml.gz)
Map and PDB model 9nid summary report (pdf.gz) Map and 9nid FULL report (pdf.gz)
EMICSS annotations (xml)

Cryo-EM structure of the PI3K alpha/KRas/HER3 phosphopeptide complex dimer on POPC/POPS/PIP2 nanodiscs low-pass filtered to 5 angstroms

EMD-49458

Single-particle
5.0 Å
EMD-49458
3D View Gallery
Deposition: 26/02/2025
Map released: 13/05/2026
Last modified: 13/05/2026
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens
Sample: full-length p85 alpha and p110 alpha heterodimer/KRas/HER3 phosphopeptide complex dimer bound to POPC/POPS/PIP2-MSP1E3D1 nanodiscs
Fitted models: 9nid

Deposition Authors: Torosyan H, Natalia J, Verba KA
Structures of the PI3K alpha /KRas complex on lipid bilayers reveal the molecular mechanism of PI3K alpha activation.
Torosyan H, Paul MD, Maker A, Meyer BG, Jura N, Verba KA
(2025) bioRxiv
PUBMED: 40196507
DOI: doi:10.1101/2025.03.22.644753
ISSN: 2692-8205