EMD-49373

Single-particle
3.6 Å
EMD-49373
3D View Gallery
Deposition: 21/02/2025
Map released: 12/11/2025
Last modified: 07/01/2026
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-49373

Archive Files (Depositor)

Primary 3D volume (map.gz) Half-map 1 Half-map 2 (map.gz) Experimental metadata (xml) Experimental metadata (cif.gz)

Validation (wwPDB)

Map-only validation report (pdf.gz) Map-9nfu summary report (pdf.gz) Map-9nfu FULL report (pdf.gz)

EMDB Annotations

EMICSS entry mapping (xml)

EMDB Files

VA raw map (map) VA resolution mask (mrc)

CryoEM Structure of De Novo Antibody Fragment scFv 6 with C. difficile Toxin B (TcdB)

EMD-49373

Single-particle
3.6 Å
EMD-49373
3D View Gallery
Deposition: 21/02/2025
Map released: 12/11/2025
Last modified: 07/01/2026
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: synthetic construct, Clostridioides difficile
Sample: Toxin B in complex with scFv 6
Fitted models: 9nfu

Deposition Authors: Weidle C, Borst AJ
Atomically accurate de novo design of antibodies with RFdiffusion.
Bennett NR, Watson JL , Ragotte RJ, Borst AJ, See DL, Weidle C, Biswas R , Yu Y , Shrock EL, Ault R, Leung PJY , Huang B, Goreshnik I, Tam J, Carr KD , Singer B , Criswell C, Wicky BIM , Vafeados D , Garcia Sanchez M , Kim HM , Vazquez Torres S, Chan S , Sun SM , Spear TT, Sun Y, O'Reilly K , Maris JM , Sgourakis NG, Melnyk RA , Liu CC , Baker D
(2026) Nature , 649 , 183 - 193
PUBMED: 41193805
DOI: doi:10.1038/s41586-025-09721-5
ISSN: 1476-4687
ASTM: NATUAS