EMD-49119

Single-particle
2.6 Å
EMD-49119
3D View Gallery
Deposition: 07/02/2025
Map released: 05/11/2025
Last modified: 22/04/2026
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-49119

Archive Files (Depositor)

Primary 3D volume (map.gz) Half-map 1 Half-map 2 (map.gz) Experimental metadata (xml) Experimental metadata (cif.gz)

Validation (wwPDB)

Map-only validation report (pdf.gz) Map-9n88 summary report (pdf.gz) Map-9n88 FULL report (pdf.gz)

EMDB Annotations

EMICSS entry mapping (xml)

EMDB Files

VA raw map (map) VA resolution mask (mrc)

PROTAC-induced IRE1 ternary complex

EMD-49119

Single-particle
2.6 Å
EMD-49119
3D View Gallery
Deposition: 07/02/2025
Map released: 05/11/2025
Last modified: 22/04/2026
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens
Sample: IRE1:G6374:VHL:Eloc:Elob
Fitted models: 9n88

Deposition Authors: Du J , Johnson M, Azumaya C, Rohou A , Hsu PL , Ashkenazi A
Chemically-induced degradation of the endoplasmic-reticulum stress sensor IRE1 by a VHL-recruiting chimera.
Du J , Villemure E, Johnson M, Azumaya C, Gaspar CJ, Marsters S, Lawrence D, Foster S, Rohou A , Cheung TK, Rose CM, Garner T, Ro S, Clark K, Beresini MH, Braun MG, Rudolph J, Hsu P, Ashkenazi A
(2025) Nat Commun , 16 , 11445 - 11445
PUBMED: 41381506
DOI: doi:10.1038/s41467-025-66382-8
ISSN: 2041-1723
Grant Support: