EMD-48922

Single-particle
3.39 Å
EMD-48922
3D View Gallery
Deposition: 04/02/2025
Map released: 15/10/2025
Last modified: 26/11/2025
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-48922

Archive Files (Depositor)

Primary 3D volume (map.gz) Half-map 1 Half-map 2 (map.gz) Experimental metadata (xml) Experimental metadata (cif.gz)

Validation (wwPDB)

Map-only validation report (pdf.gz) Map-9n5i summary report (pdf.gz) Map-9n5i FULL report (pdf.gz)

EMDB Annotations

EMICSS entry mapping (xml)

EMDB Files

VA raw map (map) VA resolution mask (mrc)

Endogenous Pfs230D13-14 in complex with Pfs48/45 bound to anti-Pfs48/45 Fabs RUPA-71 and RUPA-44

EMD-48922

Single-particle
3.39 Å
EMD-48922
3D View Gallery
Deposition: 04/02/2025
Map released: 15/10/2025
Last modified: 26/11/2025
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens, Plasmodium falciparum
Sample: Endogenous Pfs230 in complex with Pfs48/45 bound to anti-Pfs48/45 Fabs RUPA-71 and RUPA-44
Fitted models: 9n5i

Deposition Authors: Hailemariam S, Heide F, Bekkering E, Ivanochko D, Yoo R, Julien JP
Cryo-EM structure of endogenous Pfs230:Pfs48/45 complex with six antibodies reveals mechanisms of malaria transmission-blocking activity.
Bekkering ET , Yoo R, Hailemariam S, Heide F, Ivanochko D, Jackman M, Proellochs NI, Stoter R, van Gemert GJ, Maeda A, Yuguchi T, Wanders OT, van Daalen RC, Inklaar MR, Andrade CM , Jansen PWTC, Vermeulen M, Bousema T, Takashima E, Rubinstein JL, Kooij TWA, Jore MM, Julien JP
(2025) Immunity , 58 , 2899
PUBMED: 41072404
DOI: doi:10.1016/j.immuni.2025.09.014
ISSN: 1074-7613
ASTM: IUNIEH