EMD-48424
CGRP Receptor in complex with dC2_050
EMD-48424
Single-particle4.06 Å
Deposition: 21/12/2024Map released: 22/10/2025
Last modified: 22/10/2025
Sample Organism:
Homo sapiens,
synthetic construct
Sample: Complex of RAMP1, CLR, and de novo minibinder dC2_50
Fitted models: 9mni
Deposition Authors: Cao J, Cary BP, Belousoff MJ, Wootten DL
Sample: Complex of RAMP1, CLR, and de novo minibinder dC2_50
Fitted models: 9mni
Deposition Authors: Cao J, Cary BP, Belousoff MJ, Wootten DL
De novo design of miniprotein agonists and antagonists targeting G protein-coupled receptors.
Muratspahic E,
Feldman D,
Kim DE,
Qu X,
Bratovianu AM,
Rivera-Sanchez P,
Dimitri F,
Cao J,
Cary BP,
Belousoff MJ,
Keov P,
Chen Q,
Ren Y,
Fine J,
Sappington I,
Schlichthaerle T,
Zhang JZ,
Pillai A,
Mihaljevic L,
Bauer M,
Torres SV,
Motmaen A,
Lee GR,
Tran L,
Wang X,
Goreshnik I,
Vafeados DK,
Svendsen JE,
Hosseinzadeh P,
Lindegaard N,
Brandt M,
Waltenspuhl Y,
Deibler K,
Oostdyk L,
Cao W,
Anantharaman L,
Stewart L,
Halloran L,
Spangler JB,
Sexton PM,
Roth BL,
Krumm BE,
Wootten D,
Tate CG,
Norn C,
Baker D
(2025) bioRxiv
(2025) bioRxiv
Grant Support:
- National Health and Medical Research Council (NHMRC, Australia): 1150083 (Australia)
- Australian Research Council (ARC): DP210101504 (Australia)
- National Health and Medical Research Council (NHMRC, Australia): 2026300 (Australia)
- Australian Research Council (ARC): IC200100052 (Australia)