EMD-48385
CGRP Receptor in complex with C8 Minibinder
EMD-48385
Single-particle3.26 Å
Deposition: 19/12/2024Map released: 28/01/2026
Last modified: 09/09/2026
Sample Organism:
Homo sapiens,
synthetic construct
Sample: CGRP Receptor in complex with dC2_049
Fitted models: 9mm5
Deposition Authors: Cao J
,
Cary BP ,
Belousoff MJ ,
Wootten DL
Sample: CGRP Receptor in complex with dC2_049
Fitted models: 9mm5
Deposition Authors: Cao J
,
Cary BP ,
Belousoff MJ ,
Wootten DL
De novo design of miniproteins targeting GPCRs.
Muratspahic E ,
Feldman D,
Kim DE,
Qu X ,
Bratovianu AM ,
Rivera-Sanchez P,
Voss JH,
Hertz EPT ,
Jeppesen M,
Dimitri F,
Sakamoto K ,
Nallathambi A,
Peceli P,
Cao J ,
Cary BP ,
Belousoff MJ ,
Keov P ,
Trinh PNH,
Chen Q,
Ren Y ,
Fine J,
Mishra S,
Dalal A ,
Sinha S,
Banerjee R,
Ganguly M,
Karuppusamy KV,
Sappington I,
Schlichthaerle T,
Zhang JZ ,
Pillai A,
Coventry B ,
Mihaljevic L,
Bauer MS,
Torres SV,
Motmaen A ,
Lee GR ,
Tran L,
Wang X ,
Goreshnik I,
Vafeados DK ,
Svendsen JE,
Hosseinzadeh P ,
Lindegaard N ,
Brandt M ,
Waltenspuhl Y ,
Deibler K ,
Deweid L,
Bennett A,
Schoppe J ,
Dong T ,
Yan X,
Oostdyk L ,
Cao W,
Anantharaman L,
Weisser JJ,
Bastlund JF,
Bundgaard C ,
Asuni AA,
English JG,
Stewart LJ,
Halloran L,
Spangler JB ,
Lieber A,
Shukla AK ,
Sexton PM ,
Roth BL ,
Krumm BE ,
Wootten D ,
Tate CG ,
Norn C ,
Baker D
(2026) Nature , 656 , 1044 - 1053
,
Feldman D,
Kim DE,
Qu X ,
Bratovianu AM ,
Rivera-Sanchez P,
Voss JH,
Hertz EPT ,
Jeppesen M,
Dimitri F,
Sakamoto K ,
Nallathambi A,
Peceli P,
Cao J ,
Cary BP ,
Belousoff MJ ,
Keov P ,
Trinh PNH,
Chen Q,
Ren Y ,
Fine J,
Mishra S,
Dalal A ,
Sinha S,
Banerjee R,
Ganguly M,
Karuppusamy KV,
Sappington I,
Schlichthaerle T,
Zhang JZ ,
Pillai A,
Coventry B ,
Mihaljevic L,
Bauer MS,
Torres SV,
Motmaen A ,
Lee GR ,
Tran L,
Wang X ,
Goreshnik I,
Vafeados DK ,
Svendsen JE,
Hosseinzadeh P ,
Lindegaard N ,
Brandt M ,
Waltenspuhl Y ,
Deibler K ,
Deweid L,
Bennett A,
Schoppe J ,
Dong T ,
Yan X,
Oostdyk L ,
Cao W,
Anantharaman L,
Weisser JJ,
Bastlund JF,
Bundgaard C ,
Asuni AA,
English JG,
Stewart LJ,
Halloran L,
Spangler JB ,
Lieber A,
Shukla AK ,
Sexton PM ,
Roth BL ,
Krumm BE ,
Wootten D ,
Tate CG ,
Norn C ,
Baker D
(2026) Nature , 656 , 1044 - 1053
Grant Support:
- National Health and Medical Research Council (NHMRC, Australia): 1150083 (Australia)
- Australian Research Council (ARC): DP210101504 (Australia)
- National Health and Medical Research Council (NHMRC, Australia): 2026300 (Australia)
- Australian Research Council (ARC): IC200100052 (Australia)