EMD-48338

Single-particle
4.0 Å
EMD-48338
3D View Gallery
Deposition: 18/12/2024
Map released: 11/02/2026
Last modified: 11/02/2026
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-48338
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3D volume (map.gz) Experimental metadata (xml) Experimental Metadata (cif.gz)
Map-only Validation report (pdf.gz) Map-only Validation report (cif.gz) Map-only Validation report (xml.gz)
Map and PDB model 9mku summary report (pdf.gz) Map and 9mku FULL report (pdf.gz)
EMICSS annotations (xml)

FnoCas12a bridge helix variant state 2

EMD-48338

Single-particle
4.0 Å
EMD-48338
3D View Gallery
Deposition: 18/12/2024
Map released: 11/02/2026
Last modified: 11/02/2026
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Francisella tularensis subsp. novicida U112, synthetic construct
Sample: Ternary complex of FnoCRISPR-Cas12a
Fitted models: 9mku

Deposition Authors: Ganguly C, Thomas LM, Aribam SD, Martin L, Rajan R
Bridge helix of Cas12a is an allosteric regulator of R-loop formation and RuvC activation.
Ganguly C, Aribam SD, Dos Santos AM, Martin L, Thomas LM, Shao Y, Rajan R
(2026) Nat Commun
PUBMED: 41605928
DOI: doi:10.1038/s41467-026-68657-0
ISSN: 2041-1723