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EMD-48277

Composite map
Single-particle
3.2 Å
EMD-48277
3D View Gallery
Deposition: 11/12/2024
Map released: 12/02/2025
Last modified: 03/09/2025
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-48277
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3D volume (map.gz) Experimental metadata (xml) Experimental Metadata (cif.gz)
Map-only Validation report (pdf.gz) Map-only Validation report (cif.gz) Map-only Validation report (xml.gz)
Map and PDB model 9mhg summary report (pdf.gz) Map and 9mhg FULL report (pdf.gz)
EMICSS annotations (xml)

Cryo EM reconstruction of PI3KC3-C1 in complex with Human RAB1A(Q70L), VPS34 kinase domain in the inactive conformation

EMD-48277

Composite map
Single-particle
3.2 Å
EMD-48277
3D View Gallery
Deposition: 11/12/2024
Map released: 12/02/2025
Last modified: 03/09/2025
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens
Sample: Phosphatidylinositol-3 kinase class III complex I bound to RAB1A
Fitted models: 9mhg

Deposition Authors: Cook ASI , Hurley JH , Chen M
Structural pathway for PI3-kinase regulation by VPS15 in autophagy.
Cook ASI , Chen M , Nguyen TN , Cabezudo AC , Khuu G , Rao S , Garcia SN , Yang M , Iavarone AT, Ren X , Lazarou M , Hummer G , Hurley JH
(2025) Science , 388 , eadl3787 - eadl3787
PUBMED: 39913640
DOI: doi:10.1126/science.adl3787
ISSN: 1095-9203
ASTM: SCIEAS
Grant Support: