EMD-47977

Single-particle
2.96 Å
EMD-47977
3D View Gallery
Deposition: 20/11/2024
Map released: 03/12/2025
Last modified: 13/05/2026
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-47977

Archive Files (Depositor)

Primary 3D volume (map.gz) Experimental metadata (xml) Experimental metadata (cif.gz)

Validation (wwPDB)

Map-only validation report (pdf.gz) Map-9efq summary report (pdf.gz) Map-9efq FULL report (pdf.gz)

EMDB Annotations

EMICSS entry mapping (xml)

Cryo-EM structure of COP9 signalosome precatalytic state with neddylated cullin-2

EMD-47977

Single-particle
2.96 Å
EMD-47977
3D View Gallery
Deposition: 20/11/2024
Map released: 03/12/2025
Last modified: 13/05/2026
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens
Sample: The COP9 signalosome deneddylation complex with neddylated cullin-2
Fitted models: 9efq

Deposition Authors: Shi H , Zheng N
CSN5i-3 is an orthosteric molecular glue inhibitor of COP9 signalosome.
Shi H , Wang X, Yu C , Mao H, Jiao F, Braitbard M, Shor B, Zhang Z, Hinds TR, Cao S , Fan E, Schneidman-Duhovny D , Huang L , Zheng N
(2026) Nature , 652 , 1375 - 1383
PUBMED: 41673158
DOI: doi:10.1038/s41586-026-10129-y
ISSN: 1476-4687
ASTM: NATUAS
Grant Support: