EMD-47493

Single-particle
2.53 Å
EMD-47493
3D View Gallery
Deposition: 23/10/2024
Map released: 24/09/2025
Last modified: 24/09/2025
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-47493

Archive Files (Depositor)

Primary 3D volume (map.gz) Half-map 1 Half-map 2 (map.gz) Experimental metadata (xml) Experimental metadata (cif.gz)

Validation (wwPDB)

Map-only validation report (pdf.gz) Map-9e3p summary report (pdf.gz) Map-9e3p FULL report (pdf.gz)

EMDB Annotations

EMICSS entry mapping (xml)

EMDB Files

VA raw map (map) VA resolution mask (mrc)

Cryo-EM structure of the human P2X7 receptor in the UB-MBX-46-bound inhibited state

EMD-47493

Single-particle
2.53 Å
EMD-47493
3D View Gallery
Deposition: 23/10/2024
Map released: 24/09/2025
Last modified: 24/09/2025
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens
Sample: Membrane protein
Fitted models: 9e3p

Deposition Authors: Oken AC , Turcu AL , Vazquez S , Mansoor SE
A polycyclic scaffold identified by structure-based drug design effectively inhibits the human P2X7 receptor.
Oken AC , Turcu AL , Tzortzini E, Georgiou K, Nagel J , Westermann FG , Barniol-Xicota M, Seidler J, Kim GR, Lee SD, Nicke A , Kim YC, Muller CE , Kolocouris A , Vazquez S , Mansoor SE
(2025) Nat Commun , 16 , 8283 - 8283
PUBMED: 40954149
DOI: doi:10.1038/s41467-025-62643-8
ISSN: 2041-1723