EMD-47447
Glucagon Like Peptide Receptor-1 (GLP1R) A316T mutant with GLP-1 peptide. Dominant negative Gs complex.
EMD-47447
Single-particle3.3 Å
Deposition: 22/10/2024Map released: 29/10/2025
Last modified: 18/02/2026
Sample Organism:
Homo sapiens,
Lama glama
Sample: GLP-1R ternary complex
Fitted models: 9e2a
Deposition Authors: Deane-Alder K
,
Belousoff MJ ,
Wootten DL
Sample: GLP-1R ternary complex
Fitted models: 9e2a
Deposition Authors: Deane-Alder K
,
Belousoff MJ ,
Wootten DL
In vivo functional profiling and structural characterization of the human GLP1R A316T variant.
El Eid L ,
Manchanda Y ,
Austin G,
Deane-Alder K ,
Rujan RM ,
Mariam Z,
Oqua AI ,
Belousoff MJ ,
de la Serna JB ,
Sloop KW ,
Rutter GA ,
Montoya A ,
Withers DJ ,
Millership SJ ,
Bouzakri K ,
Jones B ,
Reynolds CA ,
Sexton PM ,
Wootten D ,
Deganutti G ,
Tomas A
(2026) Sci Adv , 12 , eadw0899 - eadw0899
,
Manchanda Y ,
Austin G,
Deane-Alder K ,
Rujan RM ,
Mariam Z,
Oqua AI ,
Belousoff MJ ,
de la Serna JB ,
Sloop KW ,
Rutter GA ,
Montoya A ,
Withers DJ ,
Millership SJ ,
Bouzakri K ,
Jones B ,
Reynolds CA ,
Sexton PM ,
Wootten D ,
Deganutti G ,
Tomas A
(2026) Sci Adv , 12 , eadw0899 - eadw0899
Grant Support:
- Australian Research Council (ARC): IC200100052 (Australia)
- National Health and Medical Research Council (NHMRC, Australia): #1150083 (Australia)
- Australian Research Council (ARC): DP210101504 (Australia)