EMD-47339

Single-particle
3.27 Å
EMD-47339
3D View Gallery
Deposition: 17/10/2024
Map released: 05/02/2025
Last modified: 04/02/2026
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-47339

Archive Files (Depositor)

Primary 3D volume (map.gz) Half-map 1 Half-map 2 (map.gz) Experimental metadata (xml) Experimental metadata (cif.gz)

Validation (wwPDB)

Map-only validation report (pdf.gz) Map-9dzv summary report (pdf.gz) Map-9dzv FULL report (pdf.gz)

EMDB Annotations

EMICSS entry mapping (xml)

EMDB Files

VA raw map (map) VA resolution mask (mrc)

Cryo-EM structure of the C. neoformans lipid flippase Apt1-Cdc50 in the E1 state

EMD-47339

Single-particle
3.27 Å
EMD-47339
3D View Gallery
Deposition: 17/10/2024
Map released: 05/02/2025
Last modified: 04/02/2026
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Cryptococcus neoformans var. grubii H99
Sample: Apt1-Cdc50 heterodimer
Fitted models: 9dzv

Deposition Authors: Duan HD , Li H
Butyrolactol A enhances caspofungin efficacy via flippase inhibition in drug-resistant fungi.
Chen X , Duan HD , Hoy MJ, Koteva K , Spitzer M, Guitor AK, Puumala E, Fiebig AA, Hu G, Yiu B, Chou S, Bian Z, Choi Y, Guo ABY, Wang W, Sun S , Robbins N, Averette AF, Cook MA, Truant R, MacNeil LT, Brown ED, Kronstad JW, Coombes BK, Cowen LE, Heitman J, Li H, Wright GD
(2026) Cell , 189 , 620
PUBMED: 41478284
DOI: doi:10.1016/j.cell.2025.11.036
ISSN: 1097-4172