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EMD-4631
A dimer component of alpha-1 antitrypsin polymers isolated from ZZ explant liver tissue and decorated with Fab 4B12 (component B with ~90 degree rotation around the dimer axis)
EMD-4631
Single-particle24.8 Å
Deposition: 22/02/2019Map released: 25/03/2020
Last modified: 25/11/2020
Sample Organism:
Homo sapiens,
Mus musculus
Sample: Polymers of the severe deficiency Z variant of alpha-1 antitrypsin labelled with 4B12 Fab fragments
Deposition Authors: Faull SV, Elliston ELK, Orlova EV, Gooptu B, Lomas DA, Irving JA
Sample: Polymers of the severe deficiency Z variant of alpha-1 antitrypsin labelled with 4B12 Fab fragments
Deposition Authors: Faull SV, Elliston ELK, Orlova EV, Gooptu B, Lomas DA, Irving JA
The structural basis for Z alpha 1 -antitrypsin polymerization in the liver.
Faull SV 
,
Elliston ELK ,
Gooptu B ,
Jagger AM ,
Aldobiyan I,
Redzej A ,
Badaoui M ,
Heyer-Chauhan N ,
Rashid ST ,
Reynolds GM ,
Adams DH ,
Miranda E,
Orlova EV ,
Irving JA ,
Lomas DA
(2020) Sci Adv , 6
,
Elliston ELK ,
Gooptu B ,
Jagger AM ,
Aldobiyan I,
Redzej A ,
Badaoui M ,
Heyer-Chauhan N ,
Rashid ST ,
Reynolds GM ,
Adams DH ,
Miranda E,
Orlova EV ,
Irving JA ,
Lomas DA
(2020) Sci Adv , 6
Grant Support:
- Medical Research Council (United Kingdom): MR/N024842/1 (United Kingdom)
- Other government: UCLH/NIHR Biomedical Research Centre (United Kingdom)
- Wellcome Trust: Wellcome Trust 4-year PhD Interdisciplinary Programme in Structural, Computational and Chemical Biology (United Kingdom)