EMD-45977
Structure of SH3 domain of Src in complex with beta-arrestin 1
EMD-45977
Single-particle3.47 Å
Deposition: 30/07/2024Map released: 13/11/2024
Last modified: 29/10/2025
Sample Organism:
Rattus norvegicus,
Mus musculus,
Lama glama,
Gallus gallus,
Homo sapiens
Sample: Beta-arrestin 1 bound to a G protein-coupled receptor phosphopeptide, nanobody 32 and antibody fragment Fab30 in complex with SH3 domain of Src
Fitted models: 9cx3
Deposition Authors: Pakharukova N
,
Bansia H ,
des Georges A ,
Lefkowitz RJ
Sample: Beta-arrestin 1 bound to a G protein-coupled receptor phosphopeptide, nanobody 32 and antibody fragment Fab30 in complex with SH3 domain of Src
Fitted models: 9cx3
Deposition Authors: Pakharukova N
,
Bansia H ,
des Georges A ,
Lefkowitz RJ
Mechanism of beta-arrestin 1 mediated Src activation via Src SH3 domain revealed by cryo-electron microscopy.
Pakharukova N ,
Thomas BN ,
Bansia H ,
Li L ,
Bassford DK ,
Abzalimov RR ,
Kim J,
Kahsai AW ,
Pani B ,
Xiao K,
Ochakovski R,
Liu S,
Zhang X,
Ahn S,
des Georges A ,
Lefkowitz RJ
(2025) bioRxiv
,
Thomas BN ,
Bansia H ,
Li L ,
Bassford DK ,
Abzalimov RR ,
Kim J,
Kahsai AW ,
Pani B ,
Xiao K,
Ochakovski R,
Liu S,
Zhang X,
Ahn S,
des Georges A ,
Lefkowitz RJ
(2025) bioRxiv
Grant Support:
- Howard Hughes Medical Institute (HHMI): (United States)
- National Institutes of Health/National Heart, Lung, and Blood Institute (NIH/NHLBI): HL016037-50 (United States)
- National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS): GM133598 (United States)
- Human Frontier Science Program (HFSP): LT000174/2018 (France)
- European Molecular Biology Organization (EMBO): ALTF 1071-2017 (European Union)