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EMD-45892

Single-particle
2.4 Å
EMD-45892
3D View Gallery
Deposition: 23/07/2024
Map released: 23/04/2025
Last modified: 21/05/2025
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-45892
Download
3D volume (map.gz) Experimental metadata (xml) Experimental Metadata (cif.gz)
Map-only Validation report (pdf.gz) Map-only Validation report (cif.gz) Map-only Validation report (xml.gz)
Map and PDB model 9csd summary report (pdf.gz) Map and 9csd FULL report (pdf.gz)
EMICSS annotations (xml)

The Ectodomains of SPRING and S1P with the inhibitor PF-429242

EMD-45892

Single-particle
2.4 Å
EMD-45892
3D View Gallery
Deposition: 23/07/2024
Map released: 23/04/2025
Last modified: 21/05/2025
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens
Sample: Complex of the ectodomains of S1P and SPRING in the presence of the small molecule PF-429242
Fitted models: 9csd

Deposition Authors: Kober DL
Structural basis for substrate selectivity by site-one protease revealed by studies with a small-molecule inhibitor.
Bullington AV , Micallo I , Bajaj B , Kumar P , Schlamowitz N , Silva A , Hendrix S , Zelcer N , Kober DL
(2025) PNAS , 122 , e2426931122 - e2426931122
PUBMED: 40299693
DOI: doi:10.1073/pnas.2426931122
ISSN: 1091-6490
ASTM: PNASA6
Grant Support:
  • National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS): R01GM155152 (United States)
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