EMD-45301
mouse Seipin/Adig complex
EMD-45301
Single-particle2.98 Å
Deposition: 12/06/2024Map released: 27/08/2025
Last modified: 19/11/2025
Sample Organism:
Mus musculus
Sample: Seipin/Adig complex
Fitted models: 9c8d
Deposition Authors: Li C, Han Y, Wynn RM, Chen Z, Scherer PE
Sample: Seipin/Adig complex
Fitted models: 9c8d
Deposition Authors: Li C, Han Y, Wynn RM, Chen Z, Scherer PE
Adipogenin promotes the development of lipid droplets by binding a dodecameric seipin complex.
Li C,
Sun XN,
Funcke JB,
Vanharanta L,
Prasanna X,
Gov K,
Li Y,
Virostek M,
Joung C,
Joffin N,
Kanerva K,
Szkalisity A,
Kulig W,
Straub L,
Chen S,
Velasco J,
Cobb A,
La Padula D,
Wang MY,
Onodera T,
Voros C,
Kim DS,
Kim M,
Varlamov O,
Li Y,
Liu C,
Nawrocki AR,
Zhao S,
Oh DY,
Wang ZV,
Gordillo R,
Goodman JM,
Wynn RM,
Henne WM,
Vattulainen I,
Han Y,
Ikonen E,
Scherer PE
(2025) Science , 390 , eadr9755 - eadr9755
(2025) Science , 390 , eadr9755 - eadr9755
Grant Support:
- National Institutes of Health/National Institute of Diabetes and Digestive and Kidney Disease (NIH/NIDDK): RC2-DK118620 (United States)
- National Institutes of Health/National Institute of Diabetes and Digestive and Kidney Disease (NIH/NIDDK): R01- DK55758 (United States)
- National Institutes of Health/National Institute of Diabetes and Digestive and Kidney Disease (NIH/NIDDK): R01-DK099110 (United States)
- National Institutes of Health/National Institute of Diabetes and Digestive and Kidney Disease (NIH/NIDDK): R01-DK127274 (United States)
- National Institutes of Health/National Institute of Diabetes and Digestive and Kidney Disease (NIH/NIDDK): R01-DK131537 (United States)