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EMD-44881
Structure of Src in complex with beta-arrestin 1 revealing SH3 binding sites
EMD-44881
Single-particle3.34 Å
Deposition: 14/05/2024Map released: 13/11/2024
Last modified: 27/11/2024
Sample Organism:
Rattus norvegicus,
Bacteriophage sp.,
Gallus gallus,
Homo sapiens,
Lama glama
Sample: Beta-arrestin 1 bound to a G protein-coupled receptor phosphopeptide, nanobody 32 and antibody fragment Fab30 in complex with three-domain Src (SH3-SH2-SH1).
Fitted models: 9bt8
Deposition Authors: Pakharukova N
,
Bansia H ,
Bassford DK ,
des Georges A ,
Lefkowitz RJ
Sample: Beta-arrestin 1 bound to a G protein-coupled receptor phosphopeptide, nanobody 32 and antibody fragment Fab30 in complex with three-domain Src (SH3-SH2-SH1).
Fitted models: 9bt8
Deposition Authors: Pakharukova N
,
Bansia H ,
Bassford DK ,
des Georges A ,
Lefkowitz RJ
Beta-arrestin 1 mediated Src activation via Src SH3 domain revealed by cryo-electron microscopy.
Pakharukova N ,
Thomas BN ,
Bansia H ,
Li L ,
Abzalimov RR ,
Kim J,
Kahsai AW ,
Pani B ,
Bassford DK ,
Liu S,
Zhang X,
des Georges A ,
Lefkowitz RJ
(2024) bioRxiv
,
Thomas BN ,
Bansia H ,
Li L ,
Abzalimov RR ,
Kim J,
Kahsai AW ,
Pani B ,
Bassford DK ,
Liu S,
Zhang X,
des Georges A ,
Lefkowitz RJ
(2024) bioRxiv
Grant Support:
- Howard Hughes Medical Institute (HHMI): (United States)
- National Institutes of Health/National Heart, Lung, and Blood Institute (NIH/NHLBI): HL016037-50 (United States)
- National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS): GM133598 (United States)
- European Molecular Biology Organization (EMBO): ALTF 1071-2017 (European Union)
- Human Frontier Science Program (HFSP): LT000174/2018 (France)