EMD-44597
Human proton sensing receptor GPR4 in complex with miniGs
EMD-44597
Single-particle2.8 Å
Deposition: 24/04/2024Map released: 15/01/2025
Last modified: 19/02/2025
Sample Organism:
Homo sapiens,
Lama glama
Sample: Complex of GPR4 bound to Gs heterotrimer
Fitted models: 9bip
Deposition Authors: Howard MK, Hoppe N, Huang XP, Macdonald CB
,
Mehrotra E,
Rockefeller Grimes P,
Zahm AM,
Trinidad DD,
English J,
Coyote-Maestas W,
Manglik A
Sample: Complex of GPR4 bound to Gs heterotrimer
Fitted models: 9bip
Deposition Authors: Howard MK, Hoppe N, Huang XP, Macdonald CB
,
Mehrotra E,
Rockefeller Grimes P,
Zahm AM,
Trinidad DD,
English J,
Coyote-Maestas W,
Manglik A
Molecular basis of proton sensing by G protein-coupled receptors.
Howard MK,
Hoppe N,
Huang XP,
Mitrovic D,
Billesbolle CB,
Macdonald CB ,
Mehrotra E,
Rockefeller Grimes P,
Trinidad DD,
Delemotte L,
English JG,
Coyote-Maestas W,
Manglik A
(2025) Cell , 188 , 671 - 687.e20
,
Mehrotra E,
Rockefeller Grimes P,
Trinidad DD,
Delemotte L,
English JG,
Coyote-Maestas W,
Manglik A
(2025) Cell , 188 , 671 - 687.e20
Grant Support:
- Chan Zuckerberg Initiative: (United States)
- Howard Hughes Medical Institute (HHMI): (United States)
- The Vallee Foundation Inc.: (United States)
- National Institutes of Health/National Cancer Institute (NIH/NCI): (United States)
- National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS): 5T32GM139786 (United States)
- National Institutes of Health/National Heart, Lung, and Blood Institute (NIH/NHLBI): F31HL164045 (United States)