EMD-44590
SARS-CoV-2 endoribonuclease Nsp15 bound to dsRNA with 1 nucleotide bulge
EMD-44590
Single-particle3.24 Å
Deposition: 23/04/2024Map released: 18/12/2024
Last modified: 15/01/2025
Sample Organism:
Severe acute respiratory syndrome coronavirus 2
Sample: SARS-CoV-2 endoribonuclease Nsp15 bound to dsRNA with 1 nucleotide bulge
Fitted models: 9bih
Deposition Authors: Wright ZM, Butay KJ
,
Krahn JM,
Borgnia MJ ,
Stanley RE
Sample: SARS-CoV-2 endoribonuclease Nsp15 bound to dsRNA with 1 nucleotide bulge
Fitted models: 9bih
Deposition Authors: Wright ZM, Butay KJ
,
Krahn JM,
Borgnia MJ ,
Stanley RE
Spontaneous base flipping helps drive Nsp15's preferences in double stranded RNA substrates.
Wright ZM,
Butay KJ ,
Krahn JM,
Wilson IM,
Gabel SA,
DeRose EF ,
Hissein IS,
Williams JG,
Borgnia MJ ,
Frazier MN,
Mueller GA ,
Stanley RE
(2025) Nat Commun , 16 , 391 - 391
,
Krahn JM,
Wilson IM,
Gabel SA,
DeRose EF ,
Hissein IS,
Williams JG,
Borgnia MJ ,
Frazier MN,
Mueller GA ,
Stanley RE
(2025) Nat Commun , 16 , 391 - 391
Grant Support:
- National Institutes of Health/National Institute of Environmental Health Sciences (NIH/NIEHS): ZIA ES103247 (United States)
- National Institutes of Health/National Institute of Environmental Health Sciences (NIH/NIEHS): ZIC ES103326 (United States)
- National Institutes of Health/National Institute Of Allergy and Infectious Diseases (NIH/NIAID): 1ZIAES103340 (United States)