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EMD-43932

Single-particle
4.16 Å
EMD-43932
3D View Gallery
Deposition: 06/03/2024
Map released: 17/04/2024
Last modified: 10/07/2024
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-43932
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3D volume (map.gz) Experimental metadata (xml) Experimental Metadata (cif.gz)
Map-only Validation report (pdf.gz) Map-only Validation report (cif.gz) Map-only Validation report (xml.gz)
Map and PDB model 9axc summary report (pdf.gz) Map and 9axc FULL report (pdf.gz)
EMICSS annotations (xml)

Activated CRAF/MEK heterotetramer from focused refinement of CRAF/MEK/14-3-3 complex

EMD-43932

Single-particle
4.16 Å
EMD-43932
3D View Gallery
Deposition: 06/03/2024
Map released: 17/04/2024
Last modified: 10/07/2024
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens
Sample: Activated CRAF/MEK1 heterotetramer complex from focused refinement
Fitted models: 9axc

Deposition Authors: Quade B , Cohen SE , Huang X
The Pan-RAF-MEK Nondegrading Molecular Glue NST-628 Is a Potent and Brain-Penetrant Inhibitor of the RAS-MAPK Pathway with Activity across Diverse RAS- and RAF-Driven Cancers.
Ryan MB , Quade B , Schenk N , Fang Z , Zingg M , Cohen SE , Swalm BM , Li C , Ozen A , Ye C , Ritorto MS , Huang X , Dar AC , Han Y , Hoeflich KP , Hale M , Hagel M
(2024) Cancer Discov , 14 , 1190 - 1205
PUBMED: 38588399
DOI: doi:10.1158/2159-8290.CD-24-0139
ISSN: 2159-8290
Grant Support: