EMD-43746
Plasmodium falciparum 20S proteasome bound to an inhibitor
EMD-43746
Single-particle3.1 Å
Deposition: 20/02/2024Map released: 31/07/2024
Last modified: 28/05/2025
Sample Organism:
Plasmodium falciparum 3D7
Sample: Plasmodium falciparum 20S proteasome bound with an inhibitor
Fitted models: 8w2f
Deposition Authors: Han Y, Deng X, Ray S, Chen Z, Phillips M
Sample: Plasmodium falciparum 20S proteasome bound with an inhibitor
Fitted models: 8w2f
Deposition Authors: Han Y, Deng X, Ray S, Chen Z, Phillips M
Identification of potent and reversible piperidine carboxamides that are species-selective orally active proteasome inhibitors to treat malaria.
Lawong A,
Gahalawat S,
Ray S,
Ho N,
Han Y,
Ward KE,
Deng X,
Chen Z,
Kumar A,
Xing C 
,
Hosangadi V,
Fairhurst KJ,
Tashiro K,
Liszczak G,
Shackleford DM ,
Katneni K,
Chen G,
Saunders J,
Crighton E,
Casas A,
Robinson JJ ,
Imlay LS,
Zhang X,
Lemoff A ,
Zhao Z,
Angulo-Barturen I,
Jimenez-Diaz MB,
Wittlin S,
Campbell SF,
Fidock DA,
Laleu B ,
Charman SA ,
Ready JM,
Phillips MA
(2024) Cell Chem Biol , 31 , 1503
,
Hosangadi V,
Fairhurst KJ,
Tashiro K,
Liszczak G,
Shackleford DM ,
Katneni K,
Chen G,
Saunders J,
Crighton E,
Casas A,
Robinson JJ ,
Imlay LS,
Zhang X,
Lemoff A ,
Zhao Z,
Angulo-Barturen I,
Jimenez-Diaz MB,
Wittlin S,
Campbell SF,
Fidock DA,
Laleu B ,
Charman SA ,
Ready JM,
Phillips MA
(2024) Cell Chem Biol , 31 , 1503
Grant Support:
- National Institutes of Health/National Institute Of Allergy and Infectious Diseases (NIH/NIAID): R01AI103947 (United States)
- National Institutes of Health/National Institute Of Allergy and Infectious Diseases (NIH/NIAID): R01AI155784 (United States)
- National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS): GM007062 (United States)
- Cancer Prevention and Research Institute of Texas (CPRIT): RP220582 (United States)