EMD-43712

Single-particle
2.8 Å
EMD-43712
3D View Gallery
Deposition: 14/02/2024
Map released: 19/06/2024
Last modified: 19/06/2024
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-43712

Archive Files (Depositor)

Primary 3D volume (map.gz) Half-map 1 Half-map 2 (map.gz) Experimental metadata (xml) Experimental metadata (cif.gz)

Validation (wwPDB)

Map-only validation report (pdf.gz) Map-8w0r summary report (pdf.gz) Map-8w0r FULL report (pdf.gz)

EMDB Annotations

EMICSS entry mapping (xml)

EMDB Files

VA raw map (map) VA resolution mask (mrc)

Human EBP complexed with compound 1

EMD-43712

Single-particle
2.8 Å
EMD-43712
3D View Gallery
Deposition: 14/02/2024
Map released: 19/06/2024
Last modified: 19/06/2024
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens
Sample: EBP complexed with compound 1
Fitted models: 8w0r

Deposition Authors: Sun D, Masureel M
Discovery and Optimization of Selective Brain-Penetrant EBP Inhibitors that Enhance Oligodendrocyte Formation.
Dorel R , Sun D, Carruthers N, Castanedo GM , Ung PM , Factor DC , Li T, Baumann H, Janota D, Pang J, Salphati L, Meklemburg R, Korman AJ , Harper HE, Stubblefield S, Payandeh J, McHugh D, Lang BT, Tesar PJ , Dere E, Masureel M, Adams DJ , Volgraf M, Braun MG
(2024) J Med Chem , 67 , 4819 - 4832
PUBMED: 38470227
DOI: doi:10.1021/acs.jmedchem.3c02396
ISSN: 0022-2623
ASTM: JMCMAR
Grant Support: