EMD-43676

Single-particle
4.32 Å
EMD-43676
3D View Gallery
Deposition: 09/02/2024
Map released: 28/05/2025
Last modified: 25/06/2025
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-43676
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3D volume (map.gz) Experimental metadata (xml) Experimental Metadata (cif.gz)
Map-only Validation report (pdf.gz) Map-only Validation report (cif.gz) Map-only Validation report (xml.gz)
Map and PDB model 8vyr summary report (pdf.gz) Map and 8vyr FULL report (pdf.gz)
EMICSS annotations (xml)

Cryo-EM Structure of the BRAF V600E monomer bound to GDC0879

EMD-43676

Single-particle
4.32 Å
EMD-43676
3D View Gallery
Deposition: 09/02/2024
Map released: 28/05/2025
Last modified: 25/06/2025
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens
Sample: BRAF V600E - 14-3-3 complex bound to GDC-0879
Fitted models: 8vyr

Deposition Authors: Lavoie H , Lajoie D , Jin T , Decossas M , Maisonneuve P , Therrien M
BRAF oncogenic mutants evade autoinhibition through a common mechanism.
Lavoie H , Jin T , Lajoie D , Decossas M , Gendron P , Wang B , Filandr F , Sahmi M , Hwa Jo C, Weber S , Arseneault G , Tripathy S, Beaulieu P, Schuetz DA , Schriemer DC , Marinier A , Rice WJ , Maisonneuve P , Therrien M
(2025) Science , 388 , eadp2742 - eadp2742
PUBMED: 40440367
DOI: doi:10.1126/science.adp2742
ISSN: 1095-9203
ASTM: SCIEAS