EMD-43259

Single-particle
3.52 Å
EMD-43259
3D View Gallery
Deposition: 04/01/2024
Map released: 14/08/2024
Last modified: 26/02/2025
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-43259

Archive Files (Depositor)

Primary 3D volume (map.gz) Half-map 1 Half-map 2 (map.gz) Experimental metadata (xml) Experimental metadata (cif.gz)

Validation (wwPDB)

Map-only validation report (pdf.gz) Map-8vie summary report (pdf.gz) Map-8vie FULL report (pdf.gz)

EMDB Annotations

EMICSS entry mapping (xml)

EMDB Files

VA raw map (map) VA resolution mask (mrc)

2-PPA bound human TMEM175

EMD-43259

Single-particle
3.52 Å
EMD-43259
3D View Gallery
Deposition: 04/01/2024
Map released: 14/08/2024
Last modified: 26/02/2025
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens
Sample: human TMEM175 in an inhibitor-bound state
Fitted models: 8vie

Deposition Authors: Oh S, Hite RK
Discovery of Selective Inhibitors for the Lysosomal Parkinson's Disease Channel TMEM175.
Oh S, Lee J, Choi HJ, Kim S, Sapuru V , Kim M , Hite RK
(2024) J Am Chem Soc , 146 , 23230 - 23239
PUBMED: 39116214
DOI: doi:10.1021/jacs.4c05623
ISSN: 1520-5126
ASTM: JACSAT