EMD-43149
Cryo-EM structure of human monoclonal antibody C74 targeting IT4VAR22 CIDRa1.7
EMD-43149
Single-particle3.35 Å
Deposition: 15/12/2023Map released: 02/10/2024
Last modified: 18/12/2024
Sample Organism:
Plasmodium falciparum,
Homo sapiens
Sample: Plasmodium falciparum Erythrocyte Membrane Protein 1 in complex with human monoclonal antibody
Fitted models: 8vdg
Deposition Authors: Raghavan SSR
,
Ward AB
Sample: Plasmodium falciparum Erythrocyte Membrane Protein 1 in complex with human monoclonal antibody
Fitted models: 8vdg
Deposition Authors: Raghavan SSR
,
Ward AB
Broadly inhibitory antibodies to severe malaria virulence proteins.
Reyes RA ,
Raghavan SSR ,
Hurlburt NK ,
Introini V ,
Bol S ,
Kana IH ,
Jensen RW,
Martinez-Scholze E,
Gestal-Mato M ,
Lopez-Gutierrez B ,
Sanz S ,
Bancells C,
Fernandez-Quintero ML ,
Loeffler JR,
Ferguson JA,
Lee WH ,
Martin GM,
Theander TG ,
Lusingu JPA,
Minja DTR,
Ssewanyana I,
Feeney ME ,
Greenhouse B,
Ward AB ,
Bernabeu M ,
Pancera M ,
Turner L ,
Bunnik EM ,
Lavstsen T
(2024) Nature , 636 , 182 - 189
,
Raghavan SSR ,
Hurlburt NK ,
Introini V ,
Bol S ,
Kana IH ,
Jensen RW,
Martinez-Scholze E,
Gestal-Mato M ,
Lopez-Gutierrez B ,
Sanz S ,
Bancells C,
Fernandez-Quintero ML ,
Loeffler JR,
Ferguson JA,
Lee WH ,
Martin GM,
Theander TG ,
Lusingu JPA,
Minja DTR,
Ssewanyana I,
Feeney ME ,
Greenhouse B,
Ward AB ,
Bernabeu M ,
Pancera M ,
Turner L ,
Bunnik EM ,
Lavstsen T
(2024) Nature , 636 , 182 - 189
Grant Support:
- Bill & Melinda Gates Foundation: (United States)
- Lundbeckfonden: (Denmark)