EMD-42999

Single-particle
3.0 Å
EMD-42999
3D View Gallery
Deposition: 03/12/2023
Map released: 29/05/2024
Last modified: 16/10/2024
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-42999

Archive Files (Depositor)

Primary 3D volume (map.gz) Half-map 1 Half-map 2 (map.gz) Experimental metadata (xml) Experimental metadata (cif.gz)

Validation (wwPDB)

Map-only validation report (pdf.gz) Map-8v6u summary report (pdf.gz) Map-8v6u FULL report (pdf.gz)

EMDB Annotations

EMICSS entry mapping (xml)

5HT2AR-miniGq heterotrimer in complex with a novel agonist obtained from large scale docking

EMD-42999

Single-particle
3.0 Å
EMD-42999
3D View Gallery
Deposition: 03/12/2023
Map released: 29/05/2024
Last modified: 16/10/2024
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens
Sample: Active state complex of 5HT2AR with mini-Gq heterotrimer stabilized by scFv16
Fitted models: 8v6u

Deposition Authors: Gumpper RH, Wang L , Kapolka N , Skiniotis G , Roth BL
AlphaFold2 structures guide prospective ligand discovery.
Lyu J , Kapolka N , Gumpper R, Alon A , Wang L , Jain MK , Barros-Alvarez X , Sakamoto K , Kim Y, DiBerto J , Kim K , Glenn IS , Tummino TA , Huang S, Irwin JJ , Tarkhanova OO , Moroz Y, Skiniotis G , Kruse AC , Shoichet BK , Roth BL
(2024) Science , 384 , eadn6354 - eadn6354
PUBMED: 38753765
DOI: doi:10.1126/science.adn6354
ISSN: 1095-9203
ASTM: SCIEAS