EMD-42636
Cryo-EM structure of DNMT3A1 UDR in complex with H2AK119Ub-nucleosome
EMD-42636
Single-particle2.88 Å
Deposition: 05/11/2023Map released: 11/09/2024
Last modified: 21/05/2025
Sample Organism:
Xenopus laevis,
Escherichia coli 'BL21-Gold(DE3)pLysS AG',
Homo sapiens
Sample: DNMT3A1 UDR in complex with H2AK119Ub-nucleosome
Fitted models: 8uw1
Deposition Authors: Gretarsson K
,
Abini-Agbomson S,
Armache K-J,
Lu C
Sample: DNMT3A1 UDR in complex with H2AK119Ub-nucleosome
Fitted models: 8uw1
Deposition Authors: Gretarsson K
,
Abini-Agbomson S,
Armache K-J,
Lu C
Cancer-associated DNA hypermethylation of Polycomb targets requires DNMT3A dual recognition of histone H2AK119 ubiquitination and the nucleosome acidic patch.
Gretarsson KH,
Abini-Agbomson S,
Gloor SL ,
Weinberg DN ,
McCuiston JL ,
Kumary VUS ,
Hickman AR ,
Sahu V,
Lee R ,
Xu X,
Lipieta N ,
Flashner S ,
Adeleke OA ,
Popova IK ,
Taylor HF ,
Noll K ,
Windham CL ,
Maryanski DN ,
Venters BJ ,
Nakagawa H ,
Keogh MC ,
Armache KJ ,
Lu C
(2024) Sci Adv , 10 , eadp0975 - eadp0975
,
Weinberg DN ,
McCuiston JL ,
Kumary VUS ,
Hickman AR ,
Sahu V,
Lee R ,
Xu X,
Lipieta N ,
Flashner S ,
Adeleke OA ,
Popova IK ,
Taylor HF ,
Noll K ,
Windham CL ,
Maryanski DN ,
Venters BJ ,
Nakagawa H ,
Keogh MC ,
Armache KJ ,
Lu C
(2024) Sci Adv , 10 , eadp0975 - eadp0975
Grant Support:
- National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS): R01GM115882 (United States)
- The Mark Foundation: (United States)
- National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS): 5T32GM088118 (United States)
- National Institutes of Health/National Cancer Institute (NIH/NCI): R01CA266978 (United States)