EMD-42366
Cryo-EM structure of the BG505 SOSIPv2 in complex with bNAb 04_A06 and PGDM1400 Fabs
EMD-42366
Single-particle3.8 Å
Deposition: 16/10/2023Map released: 16/04/2025
Last modified: 29/10/2025
Sample Organism:
Homo sapiens,
Human immunodeficiency virus 1
Sample: Antibody-antigen complex of HIV-1 BG505 SOSIPv2 trimer with 04_A06 and PGDM1400 Fabs
Fitted models: 8ulu
Deposition Authors: DeLaitsch AT
,
Bjorkman PJ
Sample: Antibody-antigen complex of HIV-1 BG505 SOSIPv2 trimer with 04_A06 and PGDM1400 Fabs
Fitted models: 8ulu
Deposition Authors: DeLaitsch AT
,
Bjorkman PJ
Profiling of HIV-1 elite neutralizer cohort reveals a CD4bs bnAb for HIV-1 prevention and therapy.
Gieselmann L,
DeLaitsch AT ,
Rohde M,
Gruell H ,
Kreer C ,
Ercanoglu MS,
Gristick HB,
Schommers P ,
Ahmadov E,
Radford C,
Mazzolini A ,
Zhang L,
West Jr AP ,
Worczinski J,
Momot A,
Reichwein ML,
Knufer J,
Stumpf R,
Mkhize NN ,
Kaldine H,
Bhebhe S,
Deshpande S,
Giovannoni F,
Stefanutti E,
Benigni F,
Havenar-Daughton C,
Corti D ,
Kroidl A ,
Adhikari A ,
Nanfack AJ,
Ambada GE,
Duerr R ,
Maganga L,
William W,
Ntinginya NE,
Wolf T,
Geldmacher C,
Hoelscher M ,
Lehmann C,
Moore PL ,
Mora T,
Walczak AM,
Gilbert PB,
Doria-Rose NA ,
Huang Y,
Bloom JD ,
Seaman MS,
Bjorkman PJ ,
Klein F
(2025) Nat Immunol
,
Rohde M,
Gruell H ,
Kreer C ,
Ercanoglu MS,
Gristick HB,
Schommers P ,
Ahmadov E,
Radford C,
Mazzolini A ,
Zhang L,
West Jr AP ,
Worczinski J,
Momot A,
Reichwein ML,
Knufer J,
Stumpf R,
Mkhize NN ,
Kaldine H,
Bhebhe S,
Deshpande S,
Giovannoni F,
Stefanutti E,
Benigni F,
Havenar-Daughton C,
Corti D ,
Kroidl A ,
Adhikari A ,
Nanfack AJ,
Ambada GE,
Duerr R ,
Maganga L,
William W,
Ntinginya NE,
Wolf T,
Geldmacher C,
Hoelscher M ,
Lehmann C,
Moore PL ,
Mora T,
Walczak AM,
Gilbert PB,
Doria-Rose NA ,
Huang Y,
Bloom JD ,
Seaman MS,
Bjorkman PJ ,
Klein F
(2025) Nat Immunol
Grant Support:
- Bill & Melinda Gates Foundation: INV-002143 (United States)