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EMD-42363
Cryo-EM structure of the BG505 SOSIPv2 in complex with bNAb 05_B08 Fabs
EMD-42363
Single-particle3.3 Å
Deposition: 16/10/2023Map released: 16/04/2025
Last modified: 29/10/2025
Sample Organism:
Homo sapiens,
Human immunodeficiency virus 1
Sample: Antibody-antigen complex of HIV-1 BG505 SOSIPv2 trimer with 05_B08 Fabs
Fitted models: 8ulr
Deposition Authors: DeLaitsch AT
,
Bjorkman PJ
Sample: Antibody-antigen complex of HIV-1 BG505 SOSIPv2 trimer with 05_B08 Fabs
Fitted models: 8ulr
Deposition Authors: DeLaitsch AT
,
Bjorkman PJ
Profiling of HIV-1 elite neutralizer cohort reveals a CD4bs bnAb for HIV-1 prevention and therapy.
Gieselmann L,
DeLaitsch AT ,
Rohde M,
Gruell H,
Kreer C,
Ercanoglu MS,
Gristick HB,
Schommers P,
Ahmadov E,
Radford C,
Mazzolini A,
Zhang L,
West Jr AP,
Worczinski J,
Momot A,
Reichwein ML,
Knufer J,
Stumpf R,
Mkhize NN,
Kaldine H,
Bhebhe S,
Deshpande S,
Giovannoni F,
Stefanutti E,
Benigni F,
Havenar-Daughton C,
Corti D,
Kroidl A,
Adhikari A,
Nanfack AJ,
Ambada GE,
Duerr R,
Maganga L,
William W,
Ntinginya NE,
Wolf T,
Geldmacher C,
Hoelscher M,
Lehmann C,
Moore PL,
Mora T,
Walczak AM,
Gilbert PB,
Doria-Rose NA,
Huang Y,
Bloom JD,
Seaman MS,
Bjorkman PJ ,
Klein F
(2025) Nat Immunol
,
Rohde M,
Gruell H,
Kreer C,
Ercanoglu MS,
Gristick HB,
Schommers P,
Ahmadov E,
Radford C,
Mazzolini A,
Zhang L,
West Jr AP,
Worczinski J,
Momot A,
Reichwein ML,
Knufer J,
Stumpf R,
Mkhize NN,
Kaldine H,
Bhebhe S,
Deshpande S,
Giovannoni F,
Stefanutti E,
Benigni F,
Havenar-Daughton C,
Corti D,
Kroidl A,
Adhikari A,
Nanfack AJ,
Ambada GE,
Duerr R,
Maganga L,
William W,
Ntinginya NE,
Wolf T,
Geldmacher C,
Hoelscher M,
Lehmann C,
Moore PL,
Mora T,
Walczak AM,
Gilbert PB,
Doria-Rose NA,
Huang Y,
Bloom JD,
Seaman MS,
Bjorkman PJ ,
Klein F
(2025) Nat Immunol
Grant Support:
- Bill & Melinda Gates Foundation: INV-002143 (United States)