EMD-42350

Helical reconstruction
3.9 Å
EMD-42350
3D View Gallery
Deposition: 12/10/2023
Map released: 23/10/2024
Last modified: 07/01/2026
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-42350
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3D volume (map.gz) Experimental metadata (xml) Experimental Metadata (cif.gz)
Map-only Validation report (pdf.gz) Map-only Validation report (cif.gz) Map-only Validation report (xml.gz)
Map and PDB model 8uka summary report (pdf.gz) Map and 8uka FULL report (pdf.gz)
EMICSS annotations (xml)

Structure of amplified aSyn filament by using seed amplification assay (SAA) from MSA patient CSF.

EMD-42350

Helical reconstruction
3.9 Å
EMD-42350
3D View Gallery
Deposition: 12/10/2023
Map released: 23/10/2024
Last modified: 07/01/2026
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens
Sample: Alpha-synuclein protein filament
Fitted models: 8uka

Deposition Authors: Banerjee V, Wang F, Baker ML, Serysheva II, Soto C
Seed amplification of MSA alpha-synuclein aggregates preserves the biological and structural properties of brain-derived aggregates.
Wang F, Banerjee V, Barria C, Ramirez S, Allison T, Gorski D, Evans H, Nguyen Q, Harrison D, Al-Lahham R, De Gregorio Carbonell N, Pinho M, Kaalund S, Folke J, Aznar S, Concha-Marambio L, Ishtikhar M, Mallampalli VK, Pritzkow S, Shahnawaz M, Baker ML, Serysheva I, Soto C
(2025) Nat Commun , 16 , 11266 - 11266
PUBMED: 41372188
DOI: doi:10.1038/s41467-025-66146-4
ISSN: 2041-1723