Happy Holidays and New year from the EMDB! Please be advised that the EMDB team will be operating at reduced capacity between December 15th - January 12th. With this in mind we would ask that you be prepared for longer reply times through both our helpdesk system and the OneDep deposition system. well done on a productive 2025, wishing you all the best and we will see you in 2026!
EMD-41806
C-terminal LRRK2 bound to E11 DARPin
EMD-41806
Single-particle3.7 Å
Deposition: 31/08/2023Map released: 04/09/2024
Last modified: 26/03/2025
Sample Organism:
Homo sapiens,
synthetic construct
Sample: C-terminal LRRK2 bound to E11 DARPin
Fitted models: 8u1b
Deposition Authors: Sanz-Murillo M, Mathea S
,
Dederer V,
Knapp S,
Leschziner A
Sample: C-terminal LRRK2 bound to E11 DARPin
Fitted models: 8u1b
Deposition Authors: Sanz-Murillo M, Mathea S
,
Dederer V,
Knapp S,
Leschziner A
A designed ankyrin-repeat protein that targets Parkinson's disease-associated LRRK2.
Dederer V,
Sanz Murillo M ,
Karasmanis EP ,
Hatch KS,
Chatterjee D,
Preuss F ,
Abdul Azeez KR,
Nguyen LV ,
Galicia C,
Dreier B,
Pluckthun A ,
Versees W ,
Mathea S ,
Leschziner AE,
Reck-Peterson SL,
Knapp S
(2024) J Biol Chem , 300 , 107469 - 107469
,
Karasmanis EP ,
Hatch KS,
Chatterjee D,
Preuss F ,
Abdul Azeez KR,
Nguyen LV ,
Galicia C,
Dreier B,
Pluckthun A ,
Versees W ,
Mathea S ,
Leschziner AE,
Reck-Peterson SL,
Knapp S
(2024) J Biol Chem , 300 , 107469 - 107469
Grant Support:
- Other private: ASAP-000519 (United States)