EMD-41766

Single-particle
3.2 Å
EMD-41766
3D View Gallery
Deposition: 27/08/2023
Map released: 21/08/2024
Last modified: 14/05/2025
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-41766
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3D volume (map.gz) Experimental metadata (xml) Experimental Metadata (cif.gz)
Map-only Validation report (pdf.gz) Map-only Validation report (cif.gz) Map-only Validation report (xml.gz)
Map and PDB model 8tzq summary report (pdf.gz) Map and 8tzq FULL report (pdf.gz)
EMICSS annotations (xml)

CryoEM structure of D2 dopamine receptor in complex with GoA KE mutant, scFv16, and dopamine

EMD-41766

Single-particle
3.2 Å
EMD-41766
3D View Gallery
Deposition: 27/08/2023
Map released: 21/08/2024
Last modified: 14/05/2025
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens, Escherichia coli
Sample: Human DRD2 in complex with heterotrimeric G protein GoA (K46E), scFv16, and dopamine
Fitted models: 8tzq

Deposition Authors: Krumm BE , Kapolka NJ, Fay JF , Roth BL
A neurodevelopmental disorder mutation locks G proteins in the transitory pre-activated state.
Knight KM , Krumm BE , Kapolka NJ, Ludlam WG , Cui M , Mani S , Prytkova I, Obarow EG, Lefevre TJ , Wei W , Ma N , Huang XP , Fay JF , Vaidehi N , Smrcka AV, Slesinger PA , Logothetis DE , Martemyanov KA , Roth BL , Dohlman HG
(2024) Nat Commun , 15 , 6643 - 6643
PUBMED: 39103320
DOI: doi:10.1038/s41467-024-50964-z
ISSN: 2041-1723