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EMD-41729
cryo-EM structure of GPR6-Gs-Nb35 complex
EMD-41729
Single-particle3.43 Å
Deposition: 26/08/2023Map released: 04/12/2024
Last modified: 21/05/2025
Sample Organism:
Homo sapiens,
Lama glama
Sample: GPR6-Gs-Nb35 complex
Fitted models: 8tyw
Deposition Authors: Barekatain M
,
Johansson LC,
Lam JH ,
Sadybekov AV ,
Han GW ,
Popov P,
Russo J,
Bliesath J,
Brice N,
Beresford M,
Carlson L,
Saikatendu KS ,
Sun H,
Murphy S,
Monenschein H,
Schiffer HH,
Lutomski C ,
Robinson CV ,
Liu J,
Hua T ,
Katritch V ,
Cherezov V
Sample: GPR6-Gs-Nb35 complex
Fitted models: 8tyw
Deposition Authors: Barekatain M
,
Johansson LC,
Lam JH ,
Sadybekov AV ,
Han GW ,
Popov P,
Russo J,
Bliesath J,
Brice N,
Beresford M,
Carlson L,
Saikatendu KS ,
Sun H,
Murphy S,
Monenschein H,
Schiffer HH,
Lutomski C ,
Robinson CV ,
Liu J,
Hua T ,
Katritch V ,
Cherezov V
Structural insights into the high basal activity and inverse agonism of the orphan receptor GPR6 implicated in Parkinson's disease.
Barekatain M ,
Johansson LC,
Lam JH ,
Chang H ,
Sadybekov AV ,
Han GW ,
Russo J,
Bliesath J,
Brice NL,
Carlton MBL,
Saikatendu KS ,
Sun H,
Murphy ST ,
Monenschein H,
Schiffer HH,
Popov P,
Lutomski CA,
Robinson CV ,
Liu ZJ ,
Hua T ,
Katritch V ,
Cherezov V
(2024) Sci Signal , 17 , eado8741 - eado8741
,
Johansson LC,
Lam JH ,
Chang H ,
Sadybekov AV ,
Han GW ,
Russo J,
Bliesath J,
Brice NL,
Carlton MBL,
Saikatendu KS ,
Sun H,
Murphy ST ,
Monenschein H,
Schiffer HH,
Popov P,
Lutomski CA,
Robinson CV ,
Liu ZJ ,
Hua T ,
Katritch V ,
Cherezov V
(2024) Sci Signal , 17 , eado8741 - eado8741
Grant Support: