EMD-41621
Full-length P-Rex1 in complex with inositol 1,3,4,5-tetrakisphosphate (IP4)
EMD-41621
Single-particle4.1 Å
Deposition: 15/08/2023Map released: 10/04/2024
Last modified: 10/04/2024
Sample Organism:
Homo sapiens
Sample: Complex of full-length Phosphatidylinositol 3,4,5-trisphosphate (PIP3)-dependent Rac exchanger 1 (P-Rex1) bound to inositol 1,3,4,5-tetrakisphosphate (IP4)
Fitted models: 8tua
Deposition Authors: Cash JN, Tesmer JJG
Sample: Complex of full-length Phosphatidylinositol 3,4,5-trisphosphate (PIP3)-dependent Rac exchanger 1 (P-Rex1) bound to inositol 1,3,4,5-tetrakisphosphate (IP4)
Fitted models: 8tua
Deposition Authors: Cash JN, Tesmer JJG
Full-length P-Rex1 in complex with inositol 1,3,4,5-tetrakisphosphate (IP4)
Ravala SK,
Adame-Garcia SR,
Li S,
Chen C,
Cianfrocco MA,
Gutkind JS,
Cash JN,
Tesmer JJG
(2024) eLife
(2024) eLife
Secondary citations:
- Liebschner D, Afonine PV, Baker ML, Bunkoczi G, Chen VB, Croll TI, Hintze B, Hung LW, Jain S, McCoy AJ, Moriarty NW, Oeffner RD, Poon BK, Prisant MG, Read RJ, Richardson JS, Richardson DC, Sammito MD, Sobolev OV, Stockwell DH, Terwilliger TC, Urzhumtsev AG, Videau LL, Williams CJ & Adams PD. (2019) Macromolecular structure determination using X-rays, neutrons and electrons: recent developments in Phenix. Acta Crystallogr D Struct Biol, 75, 861 - 877
- Tegunov D & Cramer P. (2019) Real-time cryo-electron microscopy data preprocessing with Warp. 16, 1146 - 1152
- Punjani A, Zhang H & Fleet DJ. (2020) Non-uniform refinement: adaptive regularization improves single-particle cryo-EM reconstruction. 17, 1214 - 1221
Grant Support:
- National Institutes of Health/National Cancer Institute (NIH/NCI): CA254402 (United States)
- National Institutes of Health/National Cancer Institute (NIH/NCI): CA221289 (United States)
- National Institutes of Health/National Heart, Lung, and Blood Institute (NIH/NHLBI): HL071818 (United States)
- National Institutes of Health/National Cancer Institute (NIH/NCI): P30CA023168 (United States)
- National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS): R35GM146664 (United States)
