Happy Holidays and New year from the EMDB! Please be advised that the EMDB team will be operating at reduced capacity between December 15th - January 12th. With this in mind we would ask that you be prepared for longer reply times through both our helpdesk system and the OneDep deposition system. well done on a productive 2025, wishing you all the best and we will see you in 2026!

EMD-41423

Single-particle
3.3 Å
EMD-41423
3D View Gallery
Deposition: 02/08/2023
Map released: 13/03/2024
Last modified: 03/04/2024
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-41423
Download
3D volume (map.gz) Experimental metadata (xml) Experimental Metadata (cif.gz)
Map-only Validation report (pdf.gz) Map-only Validation report (cif.gz) Map-only Validation report (xml.gz)
Map and PDB model 8tnp summary report (pdf.gz) Map and 8tnp FULL report (pdf.gz)
EMICSS annotations (xml)

Cryo-EM structure of DDB1dB:CRBN:Pomalidomide:SD40

EMD-41423

Single-particle
3.3 Å
EMD-41423
3D View Gallery
Deposition: 02/08/2023
Map released: 13/03/2024
Last modified: 03/04/2024
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens
Sample: Ternary Complex of DDB1dB:CRBN:pomalidomide with SD40
Fitted models: 8tnp

Deposition Authors: Roy Burman SS , Hunkeler M , Fischer ES
Continuous evolution of compact protein degradation tags regulated by selective molecular glues.
Mercer JAM , DeCarlo SJ , Roy Burman SS , Sreekanth V , Nelson AT, Hunkeler M , Chen PJ , Donovan KA , Kokkonda P, Tiwari PK , Shoba VM , Deb A, Choudhary A , Fischer ES , Liu DR
(2024) Science , 383 , eadk4422 - eadk4422
PUBMED: 38484051
DOI: doi:10.1126/science.adk4422
ISSN: 1095-9203
ASTM: SCIEAS