EMD-41233
Complex of NPR1 ectodomain with ANP plus an allosteric activating antibody, REGN5381
EMD-41233
Single-particle3.08 Å
Deposition: 12/07/2023Map released: 17/07/2024
Last modified: 20/11/2024
Sample Organism:
Homo sapiens,
Mus musculus
Sample: Active complex of NPR1 ectodomain, ANP, and REGN5381 Fab
Fitted models: 8tg9
Deposition Authors: Franklin MC, Romero Hernandez A
Sample: Active complex of NPR1 ectodomain, ANP, and REGN5381 Fab
Fitted models: 8tg9
Deposition Authors: Franklin MC, Romero Hernandez A
Agonist antibody to guanylate cyclase receptor NPR1 regulates vascular tone.
Dunn ME,
Kithcart A,
Kim JH,
Ho AJ,
Franklin MC,
Romero Hernandez A ,
de Hoon J,
Botermans W,
Meyer J ,
Jin X,
Zhang D,
Torello J,
Jasewicz D,
Kamat V,
Garnova E,
Liu N,
Rosconi M,
Pan H ,
Karnik S,
Burczynski ME,
Zheng W,
Rafique A,
Nielsen JB,
De T,
Verweij N,
Pandit A,
Locke A ,
Chalasani N,
Melander O ,
Schwantes-An TH,
Baras A ,
Lotta LA,
Musser BJ,
Mastaitis J ,
Devalaraja-Narashimha KB,
Rankin AJ,
Huang T,
Herman G,
Olson W,
Murphy AJ ,
Yancopoulos GD,
Olenchock BA,
Morton L
(2024) Nature , 633 , 654 - 661
,
de Hoon J,
Botermans W,
Meyer J ,
Jin X,
Zhang D,
Torello J,
Jasewicz D,
Kamat V,
Garnova E,
Liu N,
Rosconi M,
Pan H ,
Karnik S,
Burczynski ME,
Zheng W,
Rafique A,
Nielsen JB,
De T,
Verweij N,
Pandit A,
Locke A ,
Chalasani N,
Melander O ,
Schwantes-An TH,
Baras A ,
Lotta LA,
Musser BJ,
Mastaitis J ,
Devalaraja-Narashimha KB,
Rankin AJ,
Huang T,
Herman G,
Olson W,
Murphy AJ ,
Yancopoulos GD,
Olenchock BA,
Morton L
(2024) Nature , 633 , 654 - 661
Grant Support: