EMD-41071
Cryo-EM structure of rat cardiac sodium channel NaV1.5 with batrachotoxin analog BTX-B
EMD-41071
Single-particle3.3 Å
Deposition: 16/06/2023Map released: 06/03/2024
Last modified: 20/11/2024
Sample Organism:
Rattus norvegicus,
Aequorea victoria
Sample: Sodium channel NaV1.5 and batrachotoxinin-A 20-alpha-benzoate
Fitted models: 8t6l
Deposition Authors: Tonggu L
,
Wisedchaisri G ,
Gamal El-Din TM ,
Zheng N ,
Catterall WA
Sample: Sodium channel NaV1.5 and batrachotoxinin-A 20-alpha-benzoate
Fitted models: 8t6l
Deposition Authors: Tonggu L
,
Wisedchaisri G ,
Gamal El-Din TM ,
Zheng N ,
Catterall WA
Dual receptor-sites reveal the structural basis for hyperactivation of sodium channels by poison-dart toxin batrachotoxin.
Tonggu L ,
Wisedchaisri G ,
Gamal El-Din TM ,
Lenaeus MJ,
Logan MM,
Toma T,
Du Bois J ,
Zheng N ,
Catterall WA
(2024) Nat Commun , 15 , 2306 - 2306
,
Wisedchaisri G ,
Gamal El-Din TM ,
Lenaeus MJ,
Logan MM,
Toma T,
Du Bois J ,
Zheng N ,
Catterall WA
(2024) Nat Commun , 15 , 2306 - 2306
Grant Support:
- National Institutes of Health/National Heart, Lung, and Blood Institute (NIH/NHLBI): R01 HL112808 (United States)
- National Institutes of Health/National Institute of Neurological Disorders and Stroke (NIH/NINDS): R35 NS111573 (United States)
- National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS): R01 GM117263 (United States)
- Howard Hughes Medical Institute (HHMI): (United States)