EMD-38422
CryoEM structure of compound HNC-1664 bound with RdRP-RNA complex of SARS-CoV-2
EMD-38422
Single-particle3.29 Å
Deposition: 23/12/2023Map released: 04/12/2024
Last modified: 02/07/2025
Sample Organism:
Severe acute respiratory syndrome coronavirus,
synthetic construct,
Severe acute respiratory syndrome coronavirus 2
Sample: CryoEM structure of compound HNC-1644 bound with RdRP-RNA
Fitted models: 8xko
Deposition Authors: Li M, An L, Hong Y, Li S
,
Zhang K ,
Gong Q,
Zhang K ,
Chang C,
Li S ,
Li S
Sample: CryoEM structure of compound HNC-1644 bound with RdRP-RNA
Fitted models: 8xko
Deposition Authors: Li M, An L, Hong Y, Li S
,
Zhang K ,
Gong Q,
Zhang K ,
Chang C,
Li S ,
Li S
An adenosine analog shows high antiviral potency against coronavirus and arenavirus mainly through an unusual base pairing mode.
Jia X,
Jing X,
Li M,
Gao M,
Zhong Y,
Li E,
Liu Y,
Li R,
Yao G,
Liu Q,
Zhou M,
Hou Y,
An L,
Hong Y,
Li S ,
Zhang J,
Wang W ,
Zhang K ,
Gong P ,
Chiu S
(2024) Nat Commun , 15 , 10750 - 10750
,
Zhang J,
Wang W ,
Zhang K ,
Gong P ,
Chiu S
(2024) Nat Commun , 15 , 10750 - 10750
Grant Support:
- Other government: (China)