Happy Holidays and New year from the EMDB! Please be advised that the EMDB team will be operating at reduced capacity between December 15th - January 12th. With this in mind we would ask that you be prepared for longer reply times through both our helpdesk system and the OneDep deposition system. well done on a productive 2025, wishing you all the best and we will see you in 2026!

EMD-37978

Single-particle
3.0 Å
EMD-37978
3D View Gallery
Deposition: 04/11/2023
Map released: 06/11/2024
Last modified: 29/01/2025
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-37978
Download
3D volume (map.gz) Experimental metadata (xml) Experimental Metadata (cif.gz)
Map-only Validation report (pdf.gz) Map-only Validation report (cif.gz) Map-only Validation report (xml.gz)
Map and PDB model 8x0g summary report (pdf.gz) Map and 8x0g FULL report (pdf.gz)
EMICSS annotations (xml)

Human FL Metabotropic glutamate receptor 5, mGlu5-5M with quisqualate, Acc conformation (purified with PAM VU0409551 but not modelled)

EMD-37978

Single-particle
3.0 Å
EMD-37978
3D View Gallery
Deposition: 04/11/2023
Map released: 06/11/2024
Last modified: 29/01/2025
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens
Sample: Human FL Metabotropic glutamate receptor 5, mGlu5-5M with quisqualate and PAM VU0409551
Fitted models: 8x0g

Deposition Authors: Vinothkumar KR , Lebon G , Cannone G
Conformational diversity in class C GPCR positive allosteric modulation.
Cannone G, Berto L, Malhaire F, Ferguson G , Fouillen A , Balor S, Font-Ingles J, Llebaria A , Goudet C , Kotecha A , K R V, Lebon G
(2025) Nat Commun , 16 , 619 - 619
PUBMED: 39805839
DOI: doi:10.1038/s41467-024-55439-9
ISSN: 2041-1723