EMD-34950

Single-particle
2.95 Å
EMD-34950
3D View Gallery
Deposition: 13/12/2022
Map released: 11/10/2023
Last modified: 02/07/2025
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-34950
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3D volume (map.gz) Experimental metadata (xml) Experimental Metadata (cif.gz)
Map-only Validation report (pdf.gz) Map-only Validation report (cif.gz) Map-only Validation report (xml.gz)
Map and PDB model 8hqm summary report (pdf.gz) Map and 8hqm FULL report (pdf.gz)
EMICSS annotations (xml)

Activation mechanism of GPR132 by NPGLY

EMD-34950

Single-particle
2.95 Å
EMD-34950
3D View Gallery
Deposition: 13/12/2022
Map released: 11/10/2023
Last modified: 02/07/2025
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens, Mus musculus
Sample: Cryo-EM structure of the NPGLY-GPR132-Gi complex
Fitted models: 8hqm

Deposition Authors: Wang JL, Ding JH, Sun JP , Yu X
Functional screening and rational design of compounds targeting GPR132 to treat diabetes.
Wang JL, Dou XD , Cheng J , Gao MX, Xu GF, Ding W , Ding JH, Li Y , Wang SH, Ji ZW, Zhao XY, Huo TY, Zhang CF, Liu YM, Sha XY, Gao JR, Zhang WH, Hao Y , Zhang C, Sun JP , Jiao N , Yu X
(2023) Nat Metab , 5 , 1726 - 1746
PUBMED: 37770763
DOI: doi:10.1038/s42255-023-00899-4
ISSN: 2522-5812