Happy Holidays and New year from the EMDB! Please be advised that the EMDB team will be operating at reduced capacity between December 15th - January 12th. With this in mind we would ask that you be prepared for longer reply times through both our helpdesk system and the OneDep deposition system. well done on a productive 2025, wishing you all the best and we will see you in 2026!

EMD-34871

Single-particle
3.63 Å
EMD-34871
3D View Gallery
Deposition: 29/11/2022
Map released: 04/10/2023
Last modified: 16/10/2024
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-34871
Download
3D volume (map.gz) Experimental metadata (xml) Experimental Metadata (cif.gz)
Map-only Validation report (pdf.gz) Map-only Validation report (cif.gz) Map-only Validation report (xml.gz)
Map and PDB model 8hlb summary report (pdf.gz) Map and 8hlb FULL report (pdf.gz)
EMICSS annotations (xml)

Cryo-EM structure of biparatopic antibody Bp109-92 in complex with TNFR2

EMD-34871

Single-particle
3.63 Å
EMD-34871
3D View Gallery
Deposition: 29/11/2022
Map released: 04/10/2023
Last modified: 16/10/2024
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens, Escherichia coli (strain K12)
Sample: Cryo-EM structure of biparatopic antibody Bp109-92 in complex with TNFR2
Fitted models: 8hlb

Deposition Authors: Akiba H , Fujita J , Ise T , Nishiyama K , Miyata T , Kato T , Namba K , Ohno H , Kamada H , Nagata S , Tsumoto K
Development of a 1:1-binding biparatopic anti-TNFR2 antagonist by reducing signaling activity through epitope selection.
Akiba H , Fujita J , Ise T , Nishiyama K , Miyata T , Kato T , Namba K , Ohno H , Kamada H , Nagata S , Tsumoto K
(2023) Commun Biol , 6 , 987 - 987
PUBMED: 37758868
DOI: doi:10.1038/s42003-023-05326-8
ISSN: 2399-3642