EMD-33201

Single-particle
2.23 Å
EMD-33201
3D View Gallery
Deposition: 12/04/2022
Map released: 30/11/2022
Last modified: 03/07/2024
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-33201

Archive Files (Depositor)

Primary 3D volume (map.gz) Half-map 1 Half-map 2 (map.gz) Experimental metadata (xml) Experimental metadata (cif.gz)

Validation (wwPDB)

Map-only validation report (pdf.gz) Map-7xib summary report (pdf.gz) Map-7xib FULL report (pdf.gz)

EMDB Annotations

EMICSS entry mapping (xml)

EMDB Files

VA raw map (map) VA resolution mask (mrc)

Cryo-EM structure of human DNMT1 (aa:351-1616) in complex with ubiquitinated H3 and hemimethylated DNA analog (CXXC-disordered form)

EMD-33201

Single-particle
2.23 Å
EMD-33201
3D View Gallery
Deposition: 12/04/2022
Map released: 30/11/2022
Last modified: 03/07/2024
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens, synthetic construct
Sample: DNMT1:H3Ub2:DNAmCG/fCG Ternary complex of DNMT1 with hemi methylated DNA analog and H3Ub2
Fitted models: 7xib

Deposition Authors: Onoda H , Kikuchi A , Kori S, Yoshimi S, Yamagata A , Arita K
Structural basis for activation of DNMT1.
Kikuchi A , Onoda H , Yamaguchi K , Kori S, Matsuzawa S, Chiba Y , Tanimoto S, Yoshimi S, Sato H, Yamagata A , Shirouzu M , Adachi N , Sharif J , Koseki H , Nishiyama A , Nakanishi M, Defossez PA , Arita K
(2022) Nat Commun , 13 , 7130 - 7130
PUBMED: 36414620
DOI: doi:10.1038/s41467-022-34779-4
ISSN: 2041-1723