EMD-29321

Single-particle
2.2 Å
EMD-29321
3D View Gallery
Deposition: 28/12/2022
Map released: 09/08/2023
Last modified: 19/06/2024
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-29321
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3D volume (map.gz) Experimental metadata (xml) Experimental Metadata (cif.gz)
Map-only Validation report (pdf.gz) Map-only Validation report (cif.gz) Map-only Validation report (xml.gz)
Map and PDB model 8fnp summary report (pdf.gz) Map and 8fnp FULL report (pdf.gz)
EMICSS annotations (xml)

Structure of E138K/G140S/Q148H HIV-1 intasome with Dolutegravir bound

EMD-29321

Single-particle
2.2 Å
EMD-29321
3D View Gallery
Deposition: 28/12/2022
Map released: 09/08/2023
Last modified: 19/06/2024
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Human immunodeficiency virus 1
Sample: E138K/G140S/Q148H HIV-1 intasome bound to dolutegravir
Fitted models: 8fnp

Deposition Authors: Shan ZL, Passos DO , Strutzenberg TS , Li M , Lyumkis D
Mechanisms of HIV-1 integrase resistance to dolutegravir and potent inhibition of drug-resistant variants.
Li M , Oliveira Passos D, Shan Z , Smith SJ , Sun Q , Biswas A , Choudhuri I , Strutzenberg TS , Haldane A , Deng N , Li Z, Zhao XZ , Briganti L , Kvaratskhelia M , Burke Jr TR , Levy RM , Hughes SH , Craigie R , Lyumkis D
(2023) Sci Adv , 9 , eadg5953 - eadg5953
PUBMED: 37478179
DOI: doi:10.1126/sciadv.adg5953
ISSN: 2375-2548