Happy Holidays and New year from the EMDB! Please be advised that the EMDB team will be operating at reduced capacity between December 15th - January 12th. With this in mind we would ask that you be prepared for longer reply times through both our helpdesk system and the OneDep deposition system. well done on a productive 2025, wishing you all the best and we will see you in 2026!
EMD-29282
Cryo-EM structure of STING oligomer bound to cGAMP, NVS-STG2 and C53
EMD-29282
Single-particle2.9 Å
Deposition: 21/12/2022Map released: 01/11/2023
Last modified: 04/06/2025
Sample Organism:
Homo sapiens
Sample: STING tetramer
Fitted models: 8flm
Deposition Authors: Li J
,
Canham SM ,
Zhang X ,
Bai X ,
Feng Y
Sample: STING tetramer
Fitted models: 8flm
Deposition Authors: Li J
,
Canham SM ,
Zhang X ,
Bai X ,
Feng Y
Activation of human STING by a molecular glue-like compound.
Li J ,
Canham SM ,
Wu H,
Henault M,
Chen L,
Liu G,
Chen Y,
Yu G,
Miller HR,
Hornak V ,
Brittain SM,
Michaud GA ,
Tutter A ,
Broom W,
Digan ME,
McWhirter SM,
Sivick KE ,
Pham HT,
Chen CH,
Tria GS ,
McKenna JM ,
Schirle M ,
Mao X,
Nicholson TB ,
Wang Y,
Jenkins JL ,
Jain RK,
Tallarico JA ,
Patel SJ,
Zheng L,
Ross NT,
Cho CY,
Zhang X ,
Bai XC,
Feng Y
(2024) Nat Chem Biol , 20 , 365 - 372
,
Canham SM ,
Wu H,
Henault M,
Chen L,
Liu G,
Chen Y,
Yu G,
Miller HR,
Hornak V ,
Brittain SM,
Michaud GA ,
Tutter A ,
Broom W,
Digan ME,
McWhirter SM,
Sivick KE ,
Pham HT,
Chen CH,
Tria GS ,
McKenna JM ,
Schirle M ,
Mao X,
Nicholson TB ,
Wang Y,
Jenkins JL ,
Jain RK,
Tallarico JA ,
Patel SJ,
Zheng L,
Ross NT,
Cho CY,
Zhang X ,
Bai XC,
Feng Y
(2024) Nat Chem Biol , 20 , 365 - 372
Grant Support:
- National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS): R35GM130289 (United States)
- National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS): R01GM143158 (United States)
- Robert A. Welch Foundation: I-1702 (United States)
- Robert A. Welch Foundation: I-1944 (United States)